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KMID : 0360419830190010093
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Korean Journal of Pharmacology
1983 Volume.19 No. 1 p.93 ~ p.99
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Effect of Hydrocortisone and Furoseanide on the Renal Cyclic Nucleotides Content in Rat
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조규철/Cho, Kyu Chul
김인순/양재하/박영서/Kim, In Soon/Yang, Jae Ha/Park, Young Suh
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Abstract
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Hydrocortisone 5 mg/kg which exerts minimal effect on the renal function and furosemide 1 mg/kg which induces moderate amount of diuresis were injected intraperitoneally to study their effects on the renal cyclic nucleotides content in rats.
1) The renal tissue levels of cAMP were significantly increased by administration of hydrocortisone, but there was no significant change in the furosemide group compared with that of saline treated control group.
Moderate elevation in renal cAMP level was noted by the combined administration of hydrocortisone and furosemide, but this elevation was less than that of hydrocortisone treated group.
2) The renal cGMP level did not show nay remarkable change after the administration of hydrocortisone, however, there were a significant increase by the administration of furosemide alone or combination of both drugs.
The level of renal cGMP was higher and maintained longer in the combined treated group than furosemide treated group.
The result of this experiment indicates that the potentiating effect of hydrocortisone on the diuretic action of furosemide may be related to the renal levels of cGMP rather than that of cAMP.
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